Abstract
Cyclic tetrapeptide retrohydroxamic acids were prepared as histone deacetylase (HDAC) inhibitors and evaluated the inhibitory activity and found that they have potential as anticancer drugs.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Histone Deacetylase Inhibitors*
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Hydroxamic Acids / chemistry
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Inhibitory Concentration 50
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Ligands
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Mice
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Molecular Structure
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Oligopeptides / chemical synthesis
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Oligopeptides / pharmacology
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Peptides, Cyclic / chemical synthesis*
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Peptides, Cyclic / pharmacology*
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Structure-Activity Relationship
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Zinc / chemistry
Substances
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Antineoplastic Agents
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Enzyme Inhibitors
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Histone Deacetylase Inhibitors
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Hydroxamic Acids
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Ligands
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Oligopeptides
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Peptides, Cyclic
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Zinc